As part of its instrumentation, NCrunch needs to load and dissect the built assembly in memory in order to manipulate it. On large assemblies, this can be a memory intensive process.
Is this project being included in your solution as a project dependency, or as a referenced DLL?
To ensure compatibility with all environments, NCrunch always uses an x86 process for building and instrumenting projects. I'll make a note to test the reliability of doing this under x64, as it may perform better this way anyway.